Prodrug-activating systems in suicide gene therapy.
نویسندگان
چکیده
منابع مشابه
Prodrug Activating Systems in Suicide Gene Therapy of Cancer: a Review
Theoretically, prodrugs are relatively noncytotoxic molecules, capable of being converted to cytotoxic species only at the site of the tumor, affording enhanced antitumor selectivity. One approach aimed at enhancing the selectivity of cancer chemotherapy for solid tumors relies on the application of prodrug-activating systems in suicide gene therapy. Enzyme-activating prodrug therapy, also know...
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Current prostate cancer treatment, especially hormone refractory cancer, may create profound iatrogenic outcomes because of the adverse effects of cytotoxic agents. Suicide gene therapy has been investigated for the substitute modality for current chemotherapy because it enables the treatment targeting the cancer cells. However the classic suicide gene therapy has several profound side effects,...
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The efficacy of cancer gene therapy depends critically on "bystander effects" by which genetic modification of tumor cells results in killing of unmodified cells in the local microenvironment. In gene-dependent enzyme-prodrug therapy, expression of a prodrug-activating suicide gene is used to generate a cytotoxic metabolite that diffuses to nontransduced cells. The objective of this study was t...
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Herpes simplex virus type 1 (HSV) thymidine kinase (TK) has been widely used in suicide gene therapy for the treatment of cancer due to its broad substrate specificity and the inability of the endogenous human TK to phosphorylate guanosine analogs such as ganciclovir (GCV). The basis of suicide gene therapy is the introduction of a gene that encodes a prodrug-activating enzyme into tumor cells....
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A major focus of gene therapy for cancer has been the effort to introduce into cancer cells a number of foreign genes that encode enzymes that will selectively convert nontoxic prodrugs into toxic compounds, producing high local concentrations that result in tumor cell killing—so-called “suicide” gene therapy. A number of enzyme/prodrug systems have been described [reviewed in (1)], including h...
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 105 9 شماره
صفحات -
تاریخ انتشار 2000